Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori‑associated chronic atrophic gastritis: A follow‑up study of patients with endoscopically resected colorectal neoplasia

摘要: In a previous population-based case-control study, we demonstrated an elevated risk of colorectal neoplasia with Helicobacter pylori (H. pylori) infection. The present study investigated the effects H. pylori-associated chronic gastritis on development by analyzing recurrence subsequent to endoscopic resection. Ninety-nine patients who had undergone resection were monitored under colonoscopy, and was prospectively investigated. stage in each subject evaluated using combination two serum tests: antibody pepsinogen. cohort, recurred at rate 15,296/100,000 person-years during period. After adjusting for confounding factors, atrophic (CAG) identified as independent factor [adjusted hazard ratio (HR), 2.72; 95% confidence interval, 1.33-5.57], while pylori-infected non-atrophic not recurrent neoplasia. Colorectal earlier significantly more frequent CAG (22,573/100,000 person-years) compared without (11,089/100,000 person-years; P=0.029, log-rank test). Patients extensive showed higher recurrence. These results significant elevation establishment progression CAG, indicating involvement infection tests useful clinical markers noninvasively evaluating individual