Acute ketamine challenge increases resting state prefrontal-hippocampal connectivity in both humans and rats.

摘要: Aberrant prefrontal-hippocampal (PFC-HC) connectivity is disrupted in several psychiatric and at-risk conditions. Advances rodent functional imaging have opened the possibility that this phenotype could serve as a translational marker for research. Recent evidence from magnetic resonance (fMRI) studies has indicated an increase PFC-HC coupling during working-memory tasks both schizophrenic patients populations, contrast to decrease resting-state connectivity. Acute ketamine challenge widely used humans rats pharmacological model study mechanisms of N-methyl-d-aspartate (NMDA) receptor hypofunction context disorders. We aimed establish whether acute consistent effects by investigating fMRI thus corroborate its potential utility probe. Twenty-four healthy human subjects (12 females, mean age 25 years) received intravenous doses either saline (placebo) or (0.5 mg/kg body weight). Eighteen Sprague-Dawley male (25 mg/kg). Resting-state measurements took place after injections, data were analyzed In species, induced robust coupling, findings chronic schizophrenia. This comparison demonstrates cross-species consistency effect elucidates ketamine-induced alterations often pathological conditions, which may give clue understanding disorders their onset, help development new treatments.