Enzyme and pH dual responsive l -amino acid based biodegradable polymer nanocarrier for multidrug delivery to cancer cells
作者： Sonashree Saxena , Manickam Jayakannan
DOI: 10.1002/POLA.28216
关键词:
摘要: We report a new pH and enzyme dual responsive biodegradable polymer nanocarrier to deliver multiple anticancer drugs at the intracellular compartment in cancer cells. Natural l-aspartic acid was converted into multifunctional monomer polymerized yield classes of aliphatic polyester in-build with responsiveness. The transformation side chain BOC urethanes cationic NH3+ acidic endosomal environment disassembled polymers nanoparticles (pH trigger-1). biodegradation backbone by esterase ruptured nanoassemblies released cytoplasm (trigger-2). scaffolds were capable delivering such as doxorubicin, topotecan, curcumin (CUR). cytotoxicity nascent drug-loaded tested cervical (HeLa) breast (MCF-7) cell lines. nanoscaffolds found be nontoxic cells whereas their exhibited excellent killing. Confocal microscopic images revealed that taken up degradation process delivered nucleus established proof-of-concept. present investigation opens platform for l-amino based scaffolds, first time, drug delivery treatment. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Chem. 2016, 54, 3279–3293
harvard.edu
sci-hub.se 参考文章(49)
Rajendra Aluri, Manickam Jayakannan, One-pot two polymers: ABB′ melt polycondensation for linear polyesters and hyperbranched poly(ester-urethane)s based on natural l -amino acids Polymer Chemistry. ,vol. 6, pp. 4641- 4649 ,(2015) , 10.1039/C5PY00602C
Autumn Carlsen, Sébastien Lecommandoux, Self-assembly of polypeptide-based block copolymer amphiphiles Current Opinion in Colloid & Interface Science. ,vol. 14, pp. 329- 339 ,(2009) , 10.1016/J.COCIS.2009.04.007
P. S. Pramod, Kathryn Takamura, Sonali Chaphekar, Nagaraj Balasubramanian, M. Jayakannan, Dextran Vesicular Carriers for Dual Encapsulation of Hydrophilic and Hydrophobic Molecules and Delivery into Cells Biomacromolecules. ,vol. 13, pp. 3627- 3640 ,(2012) , 10.1021/BM301583S
Jason Mattia, Paul Painter, A Comparison of Hydrogen Bonding and Order in a Polyurethane and Poly(urethane−urea) and Their Blends with Poly(ethylene glycol) Macromolecules. ,vol. 40, pp. 1546- 1554 ,(2007) , 10.1021/MA0626362
Kai Guo, C. C. Chu, Synthesis, characterization, and biodegradation of novel poly(ether ester amide)s based on L-phenylalanine and oligoethylene glycol. Biomacromolecules. ,vol. 8, pp. 2851- 2861 ,(2007) , 10.1021/BM070158C
Adrian V. Fuchs, Niklas Kotman, Julien Andrieu, Volker Mailänder, Clemens K. Weiss, Katharina Landfester, Enzyme cleavable nanoparticles from peptide based triblock copolymers Nanoscale. ,vol. 5, pp. 4829- 4839 ,(2013) , 10.1039/C3NR00706E
Timothy J. Deming, Synthetic polypeptides for biomedical applications Progress in Polymer Science. ,vol. 32, pp. 858- 875 ,(2007) , 10.1016/J.PROGPOLYMSCI.2007.05.010
Helin Xu, Qing Yao, Cuifang Cai, Jinxin Gou, Yu Zhang, Haijun Zhong, Xing Tang, Amphiphilic poly(amino acid) based micelles applied to drug delivery: the in vitro and in vivo challenges and the corresponding potential strategies. Journal of Controlled Release. ,vol. 199, pp. 84- 97 ,(2015) , 10.1016/J.JCONREL.2014.12.012
P. S. Pramod, Ruchira Shah, Manickam Jayakannan, Dual stimuli polysaccharide nanovesicles for conjugated and physically loaded doxorubicin delivery in breast cancer cells. Nanoscale. ,vol. 7, pp. 6636- 6652 ,(2015) , 10.1039/C5NR00799B
Ramille N. Shah, Nirav A. Shah, Marc M. Del Rosario Lim, Caleb Hsieh, Gordon Nuber, Samuel I. Stupp, Supramolecular design of self-assembling nanofibers for cartilage regeneration Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 3293- 3298 ,(2010) , 10.1073/PNAS.0906501107