The membrane binding of morphine, diphenylhydantoin, and tetrahydrocannabinol.

摘要: The adsorption of morphine to guinea pig brain synaptosome membranes and human erythrocyte was found be passive, unaffected by time, temperature, ouabain, dinitrophenol, saponin, or ATP. membrane/buffer partition coefficient for 35 (at low ionic strength) 1.2 high strength). diphenylhydantoin around 60 pH 8), while that Δ9-tetrahydrocannabinol (THC) 380 (in the concentration range 10−5 M). latter drug dropped a factor two three with increasing concentrations both ghosts synaptosomes; there may types binding sites THC. minimum blocking (frog sciatic nerve) were 1.1 × 10−2 M morphine, 8.3 × 10−4 M diphenylhydantoin. anesthetizing membrane these drugs are close value predicted Meyer–Overton rule local anesthesia (3...