Cell Lineage-Based Stratification for Glioblastoma.

摘要: Glioblastoma, the predominant adult malignant brain tumor, has been computationally classified into molecular subtypes whose functional relevance remains to be comprehensively established. Tumors from genetically engineered glioblastoma mouse models initiated by identical driver mutations in distinct cells of origin portray unique transcriptional profiles reflective their respective lineage. Here, we identify corresponding human and describe patient-derived xenografts with species-conserved subtype-discriminating properties. The oligodendrocyte lineage-associated subtype requires ERBB3 harbors therapeutic sensitivities. These results highlight importance cell lineage independent provide a methodology for classification future clinical investigations.