Distance and pairing effects on the brownDominant heterochromatic element in Drosophila.

摘要: We examined the behavior of brownDominant (bwD) heterochromatic insertion moved to different locations relative centric heterochromatin. Effects were measured as degree silencing a wild-type brown eye pigment gene by bwD across tandem duplication. A series X-ray-induced effects recovered at high frequency. Cis-acting enhancers obtained relocation duplication closer autosomal Enhancers also on homologous chromosome when it was similarly rearranged, revealing novel interhomologue effect whereby interactions occur between genetic elements near opposite ends arm rather than paired alleles. suppressors secondary rearrangements in which farther away from Suppression correlated with loss cytological association and polytene chromocenter. Surprisingly, distance chromocenter not strength enhancement or suppression. propose that fails coalesce its position along places beyond threshold heterochromatin, this depends upon configuration both carrying homologue.