Chromosomally-induced meiotic drive in Drosophila males: checkpoint or fallout?

摘要: In male Drosophila melanogaster, anomalies in sex chromosome pairing at meiosis often lead to complete or partial sperm dysfunction. This observation has led the suggestion that defects either efficiency configuration of metaphase trigger a checkpoint mechanism leads elimination meiotic products. Here, we discuss this model consideration recent observations on conservation components meiosis, and phenotype new alleles male-specific mutant teflon. Based these observations, propose an alternative hypothesis for cause dysfunction cases chromosomal sterility drive. We suggest disruption prophase compartmentalization chromatin, rather than abnormal metaphase, may be causative defect. Such occur as result perturbations pairing, by translocations involving autosomal chromatin. how account previously described examples causes drive Drosophila.