Intensity-modulated radiotherapy followed by a brachytherapy boost for oropharyngeal cancer.
作者： Abrahim Al‐Mamgani , Peter C Levendag , Peter van Rooij , Cees A Meeuwis , Aniel Sewnaik
DOI: 10.1002/HED.23244
关键词:
摘要: Background The purpose of this study was to reduce the incidence radiation-induced toxicity in patients with early-stage oropharyngeal cancer, using highly conformal radiation techniques. Methods Between 2000 and 2011, 167 T1-3N0-3 cancer were treated 46-Gy intensity-modulated therapy (IMRT) followed by 22-Gy brachytherapy boost. In node-positive disease, neck dissection performed. Results The 5-year Kaplan–Meier estimates local control, regional disease-free survival (DFS), overall (OS) 94%, 97%, 84%, 72%, respectively. Feeding tubes required 26% patients. Grade ≥2 late xerostomia dysphagia 11% 8%, Chemotherapy, tumor subsite, bilateral irradiation correlate significantly toxicity. Quality life (QOL) scores deteriorate during shortly after treatment but returned all scales baseline within 6 12 months, exception xerostomia. Conclusion Brachytherapy boost (in cancer) IMRT resulted excellent outcomes low good QOL scores. © 2013 Wiley Periodicals, Inc. Head Neck 35: 1689–1697, 2012
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