Metformin-diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome.
作者： C.J. Glueck , D. Aregawi , M. Winiarska , M. Agioria , G. Luo
DOI: 10.1515/JPEM.2006.19.6.831
关键词:
摘要: Background: In 35 adolescent females (17 ± 2 years) with polycystic ovary syndrome (PCOS), median body mass index (BMI) 30.8 kg/m , we assessed effeicacy of metformin-diet for 1 year reduction weight, insulin, HOMA insulin resistance (IR), cholesterol, triglycerides, and resumption regular menses. Methods: Calories (26% protein, 44% carbohydrate) were targeted to 1,500-1,800/day if BMI was <25 or 1,200-1,500/day ≥25, along 2,550 mg metformin. Results: Median weight fell from 82.7 79.1 kg (p = 0.009), insulins 16.7 13.3 μU/ml <0.0001), IR 3.41 2.74 0.0004), total cholesterol 164 151 mg/dl 0.002), triglyceride 103 85 0.006). The percentage cycles normal menses rose a pre-treatment mean 22% 74%, p < 0.0001. Conclusions: adolescents PCOS, reduces IR, facilitates
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