Low-dose versus standard-dose lenograstim prophylaxis after chemotherapy: a randomized, crossover comparison.
作者： G C Toner , J D Shapiro , C R Laidlaw , D Rischin , M J Millward
DOI: 10.1200/JCO.1998.16.12.3874
关键词:
摘要: PURPOSEGranulocyte colony-stimulating factor (G-CSF) administered prophylactically after chemotherapy reduces the duration and severity of neutropenia. This randomized crossover study was designed to assess whether a lower dose G-CSF is as effective standard 5 microg/kg daily.PATIENTS AND METHODSPatients who received standard-dose regimens expected cause neutropenia (lenograstim) that started day for 14 days or until absolute neutrophil count (ANC) recovered greater than 10 x 10(9)/L. The lenograstim randomly allocated be 2 daily in first cycle crossed over alternate second cycle. accrue 40 assessable patients provide power 80% detect difference 1 day. Fifty-two were treatment 43 completed two cycles identical chemotherapy.RESULTSThere little neutrop...
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