Atrial fibrillation and incidence of dementia A systematic review and meta-analysis

摘要: Background: Previous systematic reviews that examined whether atrial fibrillation (AF) is associated with dementia have relied on different study designs (including retrospective ones) and did not evaluate risk using meta-analysis. Methods: We searched Medline, Embase, PsychINFO in September 2010 for published prospective studies reporting the association between baseline AF incident dementia. Pooled odds ratios were calculated random effects model, heterogeneity assessed I 2 . Results: identified 15 relevant covering 46,637 participants, mean age 71.7 years. One reported no significant difference Mini-Mental State Examination scores patients or without could be pooled. Meta-analysis of remaining 14 showed was a increase overall (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.4 to 2.7, p = 75%). When stratified by (with little heterogeneity) focusing solely stroke (7 studies, OR 2.4, CI 1.7 3.5, 10%), borderline significance substantial broader populations 1.6, 1.0 0.05, 87%). For conversion mild cognitive impairment dementia, one (OR 4.6, 12.5). Conclusion: There consistent evidence supporting an increased incidence whereas there remains considerable uncertainty about any link population. The potential merits further investigation.