Potential role of APRIL as autocrine growth factor for megakaryocytopoiesis.

摘要: A proliferation-inducing ligand (APRIL) is a new tumor necrosis factor family member implicated in cell proliferation. We investigated the role of APRIL megakaryocytopoiesis, developmental hematopoietic process responsible for progenitor differentiation to megakaryoblasts and megakaryocytes, leading platelet formation. not expressed CD34+ cells from healthy donors, but it massively up-regulated during proliferative phase megakaryocytic differentiation. Exogenous expression primary increases growth, suggesting that acts as megakaryocytopoiesis. More importantly, neutralization endogenous was able dramatically reduce megakaryocyte expansion production. Thus, our data provide evidence growth terminal megakaryocytopoiesis may promote physiologic