Peptidoleukotriene (pLT) release from guinea pig lung mast cells.
作者： Owen Doran , Jim Stahl , Ellen Cook , Carl K. Buckner , Frank M. Graziano
DOI: 10.1007/BF01534601
关键词:
摘要: Guinea pig lung mast cells can be isolated and purified to high purity. This has given us the opportunity study in greater detail mediator release from these cells. Both immunologic (ovalbumin sensitized) nonimmunologic (calcium ionophore, Cal) stimuli caused a dose-dependent of histamine pLT monodispersed highly Examination time curve for revealed 5-min lag this peak at 60 min after challenge with antigen. Verification was obtained by use 5-lipoxygenase inhibitor A64077 (Zileuton). Pretreatment prevented either antigen or Cal but had no appreciable effect on (HR). The pulmonary cell appears an important contributor guinea lung.
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