Biological screening, DNA interaction studies, and catalytic activity of organotin(IV) 2-(4-ethylbenzylidene) butanoic acid derivatives: synthesis, spectroscopic characterization, and X-ray structure

摘要: A series of organotin(IV) carboxylates, [Me2SnL2] (1), [Bu2SnL2] (2), [Oct2SnL2] (3), [Me3SnL] (4), and [Ph3SnL] (5), where L = 2-(4-ethylbenzylidene) butanoic acid, have been synthesized characterized by elemental analysis, FT-IR, NMR (1H, 13C, 119Sn). (4) was analyzed single crystal X-ray analysis which showed polymeric structure with distorted trigonal bipyramidal geometry. The complexes were screened for biological activities including antibacterial, antifungal, cytotoxic activities. UV–vis absorption studies HL, 1 4 SS-DNA revealed groove binding as well intercalation, may be due to the presence planar phenyl groups that facilitate interaction DNA. determined intrinsic constants, 6.04 × 103 M−1 (HL), 9.6 × 103 M−1 1.7 × 104 M−1 HL less strength than 4. catalytic di- tri-organotin(IV) assessed in transesterification triglycerides (linseed oil) into f...