Effects of chronic consumption of metanil yellow by developing and adult rats on brain regional levels of noradrenaline, dopamine and serotonin, on acetylcholine esterase activity and on operant conditioning.
作者： T.N. Nagaraja , T. Desiraju
DOI: 10.1016/0278-6915(93)90177-Z
关键词:
摘要: Metanil yellow is the principal non-permitted food colour used extensively in India. The effects of long-term consumption metanil on developing and adult brain were studied using Wistar rats. Regional levels noradrenaline, dopamine serotonin, activity acetylcholine esterase (AChE), operant conditioning with reward assessed rats fed, controls. In treated amine hypothalamus, striatum stem significantly affected, changes not generally reversible even after withdrawal showed an early reduction AChE activity, whereas hippocampus a delayed but persistent effect reduced activity. Treated also took more sessions to learn behaviour. These these major neurotransmitter systems learning, indicate that chronic can predispose both central nervous system (CNS) rat neurotoxicity.
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