Gr-1dimCD11b+ Immature Myeloid-Derived Suppressor Cells but Not Neutrophils Are Markers of Lethal Tuberculosis Infection in Mice
作者： Evgeny N. Tsiganov , Elena M. Verbina , Tatiana V. Radaeva , Vasily V. Sosunov , George A. Kosmiadi
关键词:
摘要: Tuberculosis (TB) disease may progress at different rates and have outcomes. Neutrophils been implicated in TB progression; however, data on their role during are controversial. In this study, we show that mice, progression is associated with the accumulation of cells express neutrophilic markers Gr-1 Ly-6G but do not belong to conventional neutrophils. The exhibit unsegmented nuclei, dim CD11b + phenotype, F4/80, CD49d, Ly-6C, CD117, CD135 characteristic neutrophils immature myeloid cells. accumulate lungs, bone marrow, spleen, blood advanced (prelethal) stage Mycobacterium tuberculosis infection represent a heterogeneous population stages differentiation. accompanied by disappearance (Gr-1 hi –expressing cells). suppress T cell proliferation IFN-γ production vitro via NO-dependent mechanisms, is, they characteristics myeloid-derived suppressor These results document generation TB, suggesting pathogenesis, arguing contribute pathology stage.
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