Analyses of the Similarity and Difference of Global Gene Expression Profiles in Cortex Regions of Three Neurodegenerative Diseases: Sporadic Creutzfeldt-Jakob Disease (sCJD), Fatal Familial Insomnia (FFI), and Alzheimer’s Disease (AD)

摘要: Neurodegenerative disease is a general designation for the disorders that are progressive loss of structure or function and final death neurons, including Alzheimer's, Parkinson's, Huntington's, prion diseases, etc. In this study, we comparatively analyzed 21 individual microarray data sets cortex tissues from 11 sporadic Creutzfeldt-Jakob (sCJD), 3 fatal familial insomnia (FFI), Alzheimer's (AD), 4 normal controls. After normalization, collection 730 differently expressed (DESets) were obtained by comparison three diseases with their original Principal component analysis (PCA) showed background-related distribution within groups FFI, AD, control, but two apparently different subgroups group sCJD observed. Review clinical materials patients identified difference in brain PrP(Sc) deposits between subgroups. Hierarchical cluster illustrated relatively independent clusters controls, FFIs, six cases (subgroup 1) more deposits, respectively, while an overlapped five sCJD2 2) less AD patients. Despite presence special gene expressions, many common features found among those neurodegenerative diseases. The most commonly changed biological processes (BPs) signal transduction, synaptic transmission, neuropeptide signaling pathway. pathways MAPK pathway, Parkinson's disease, oxidative phosphorylation. Our here provide similarity global expressions sCJD, which may help to understand mechanism