Altered acylated ghrelin response to food intake in congenital generalized lipodystrophy

摘要: Background Patients with congenital generalized lipodystrophy (CGL) have very low levels of leptin and are described as having a voracious appetite. However, direct comparison between CGL eutrophic individuals is lacking, regarding both appetite parameters acylated ghrelin, the hormone form that active in acute food intake stimulation. The objective present study was to address whether what extent subjective ghrelin response meal affected individuals, individuals. Additionally, an obese group included study, allow leptin-resistant leptin-deficient condition on these aspects. Methods Eutrophic controls (EUT, n = 10), subjects (OB, 10) (n 11) were fasted overnight then received ad libitum meal. Blood collected visual analogue scale applied before 90 minutes after An additional blood sample at 60 for determination. Results patients showed fasting adiponectin, dyslipidemia, insulin resistance. caloric similar among 3 groups. (p 0.02) OB 0.04) had shorter satiation times than EUT. also lower satiety time 0.01) their sensation hunger less attenuated by 0.03). Fasting EUT 0.003). After meal, tended decrease but not Conclusion data indicate that, although hyperphagic, disturbances relation Their absence physiological drop suggest role attenuation satiation.