Error analysis of table look-up method for cerebral blood flow measurement by123I-IMP brain SPECT: Comparison with conventional microsphere model method

摘要: While N-isopropyl-p-[123I]iodoamphetamine (IMP) is commonly used as a flow tracer, significant clearance from the brain causes underestimation of CBF compared with true when conventional microsphere model analysis applied. We previously reported simple “table lookup” method for measurement using IMP taking into account this effect. The based on two-compartment model, K1 (corresponding to CBF) and k2 constants being obtained table ratio 1st SPECT (40 min) 2nd (180 counts. Arterial input data were by one point blood sampling 10 min after infusion against standard function. In present study, approach was analysis. For 30 subjects, latter entailed 8 continuous arterial use at end period, calibrated count min/40 planar images whole brains. A good correlation observed between two methods (r = 0.88), but an overestimation look-up contrary theoretical predictions. Limitations in estimation min, 40 calibration images, might be responsible this.