Genetic approaches to modeling anxiety in animals

摘要: Anxiety disorders are a growing health problem world-wide. However, the causative factors, etiology, and underlying mechanisms of anxiety disorders, as for most psychiatric remain relatively poorly understood. The current status clinical research indicates that traits disorder in man have genetic component, therefore modeling animals is logical approach to gain greater insight into their neurobiology. it also clear nature these contributions highly complex. Moreover, success this largely contingent upon utility available behavioral paradigms anxiety-related behaviors mice. Animal models provide unique comprehensive methodological tool aid discovery neurobiology, ultimately, therapy human disorders. approach, however, challenged with number complexities. In particular, heterogeneous coupled associated multifaceted descriptive diagnostic criteria, create challenges both animal research. article, we describe some powerful modem techniques uniquely amenable laboratory mouse thus strategy approaching challenges. focus on recent advances which highlighted relative contribution understanding neurobiology basis