Onset of opportunity to use cannabis and progression from opportunity to dependence: Are influences consistent across transitions?

摘要: Abstract Background There is a developing body of research looking at cannabis use opportunity, but little examining timing opportunity to cannabis. Aims Identify factors associated with (1) earlier and (2) faster progression from dependence. Method Cross-sectional study 3824 Australian twins siblings, measuring age onset DSM-IV Survival analysis identified or Results Factors both speed dependence were conduct disorder (opportunity HR 5.57, 95%CI 1.52–20.47; 2.49, 1.91–3.25), parental drug problems 7.29, 1.74–30.62; 3.30, 1.63–6.69), weekly tobacco 8.57, 3.93–18.68; 2.76, 95% CI 2.10–3.64), female gender 0.69, 0.64–0.75; 0.44, 0.34–0.55). Frequent childhood religious attendance (HR 0.74, 0.68–0.80), conflict 1.09, 1.00–1.18), alcohol 1.19, 1.08–1.30) sexual abuse 1.17, 1.01–1.34) uniquely transition opportunity. Depressive episode 1.44, 1.12–1.85), 1.36, 1.04–1.78), 2.64, 1.53–4.58), other 2.10, 1.64–2.69) 2.75, 1.70–4.43) Conclusion The profile only partially overlaps, suggesting targeting interventions may benefit being tailored the stages use.