Genetic and Environmental Interplay in Adolescent Substance Use Disorders

摘要: Adolescent substance use is of considerable public health importance. This narrative review provides a brief background to genetically informative research methodologies and highlights key recent literature examining the interplay between genetic environmental influences in etiology use. Twin studies have quantified magnitude influences, more recently co-relative Children designs shown environments can moderate heritability. Studies identified number specific gene variants (e.g. OPRM1, DRD4, 5HTTLPR) that interact with parenting peer influence, effectiveness interventions may vary by genotype. However, little has taken into account stage-sequential nature obscure important differences their interplay, at stages escalation problem Future needs build on existing disentangle complexities progression adolescent