Genetic Influences on Alcohol Use across Stages of Development: GABRA2 and Longitudinal Trajectories of Drunkenness from Adolescence to Young Adulthood
作者： Danielle M. Dick , Seung Bin Cho , Shawn J. Latendresse , Fazil Aliev , John I. Nurnberger
DOI: 10.1111/ADB.12066
关键词: Psychology 、 Young adult 、 Genetic association 、 GABRA2 、 Erikson's stages of psychosocial development 、 Genetic risk 、 Alcohol dependence 、 Rate of increase 、 Developmental psychology 、 Early adolescence
摘要: Longitudinal analyses allow us to understand how genetic risk unfolds across development, in a way that is not possible with cross-sectional of individuals at different ages. This has received little attention association analyses. In this study, we test for effects GABRA2, gene previously associated alcohol dependence, on trajectories drunkenness from age 14 25. We use data 1070 who participated the prospective sample Collaborative Study Genetics Alcoholism (COGA), order better unfolding development. Piecewise linear growth models were fit model influence genotype rate increase early adolescence young adulthood (14–18 years), change during transition (18–19 and (≥ 19 years). Variation GABRA2 was an occurred between adulthood. The genotypic effect more pronounced females. These illustrate importance longitudinal characterize unfold findings suggest transitions important developmental periods may alter relative patterns use. also considering gender when evaluating drinking males
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