Biodistribution and bioactivity of tetra-pegylated meta-tetra(hydroxyphenyl)chlorin compared to native meta-tetra(hydroxyphenyl)chlorin in a rat liver tumor model.
作者： Jeroen P. Rovers , Anne E. Saarnak , Martin de Jode , Hendricus J. C. M. Sterenborg , Onno T. Terpstra
DOI: 10.1562/0031-8655(2000)071<0211:BABOTP>2.0.CO;2
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摘要: Abstract It has been proposed that the construction of a photosensitizer–polymer conjugate would lead to an increased selective retention drug in tumor tissue resulting enhancement destruction by light photodynamic therapy. In this study kinetics tetra-pegylated derivative meta-tetra(hydroxyphenyl)chlorin (mTHPC–PEG) were compared with those native (mTHPC) rat liver model. addition, time course bioactivity both drugs was studied normal tissue. Pegylation mTHPC resulted two-fold increase plasma half-life time, five-fold decrease uptake and selectivity at early intervals after administration. However, although concentrations rapidly mTHPC–PEG as function time. This led loss all but earliest points, whereas sel...
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