Hyaluronan and the Aggregating Proteoglycans
作者： Thomas N. Wight , Bryan P. Toole , Vincent C. Hascall
DOI: 10.1007/978-3-642-16555-9_5
关键词:
摘要: Proteoglycans that interact specifically with hyaluronan are known as the “hyalectins”. This family includes aggrecan, versican, neurocan, and brevican. These proteoglycans form macromolecular complexes contribute to structural mechanical stability of different tissues. The synthesis turnover individual components these highly regulated. In addition, parts cells influence cellular phenotype. Specific qualitative quantitative changes take place in macromolecules during development disease and, part, regulate key events determine normal pathological tissue chapter reviews both past present evidence for critical role ECM play biology pathology human
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