Mapping of Chromosomal Imbalances in Pancreatic Carcinoma by Comparative Genomic Hybridization

摘要: To identify recurrent chromosomal imbalances in pancreatic adenocarcinoma, 27 tumors were analyzed by using comparative genomic hybridization. In 23 cases found. Gains of material much more frequent than losses. The most common overrepresentations observed on chromosomes 16p (eight cases), 20q (seven 22q (six and 17q (five cases) underrepresentations a subregion chromosome 9p cases). Distinct high-level amplifications found 1p32-p34, 6q24, 7q22, 12p13, 22q. These data provide evidence for number new cytogenetically defined aberrations which are characteristic carcinoma. overrepresented or underrepresented regions represent candidate potential oncogenes tumor suppressor genes, respectively, possibly involved tumorigenesis.