A reaction–diffusion model for radiation-induced bystander effects

摘要: We develop and analyze a reaction-diffusion model to investigate the dynamics of lifespan bystander signal emitted when cells are exposed radiation. Experimental studies by Mothersill Seymour 1997, using malignant epithelial cell lines, found that an can still cause effects in even 60 h after its emission. Several other experiments have also shown persist for months years. Also, been hypothesized as one factors responsible phenomenon low-dose hyper-radiosensitivity increased radioresistance (HRS/IRR). Here, we confirm this hypothesis with mathematical model, which fit Joiner's data on HRS/IRR T98G glioma line. Furthermore, use phase plane analysis understand full signal's lifespan. find both single multiple radiation exposure lead signals either temporarily or permanently. that, heterogeneous environment, size domain number exposures determine whether will Finally, sensitivity identify those parameters affect signal-induced death most.