Impact of Vitamin A and Carotenoids on the Risk of Tuberculosis Progression.

摘要: Background Low and deficient levels of vitamin A are common in low- middle-income countries where tuberculosis burden is high. We assessed the impact baseline carotenoids on disease risk. Methods conducted a case-control study nested within longitudinal cohort household contacts (HHCs) pulmonary case patients Lima, Peru. defined as human immunodeficiency virus (HIV)-negative HHCs with blood samples whom developed ≥15 days after enrollment index patient. For each patient, we randomly selected 4 controls from among did not develop, matching for sex year age. used conditional logistic regression to estimate odds ratios incident by levels, controlling other nutritional socioeconomic factors. Results Among 6751 HIV-negative samples, 192 had secondary during follow-up. analyzed 180 viable 709 matched controls. After possible confounders, found that deficiency was associated 10-fold increase risk (adjusted ratio, 10.53; 95% confidence interval, 3.73-29.70; P < .001). This association dose dependent, stepwise increases decreasing quartile level. Conclusions Vitamin strongly predicted tuberculosis. supplementation individuals at high may provide an effective means preventing disease.