24R,25-dihydroxycholecalciferol to treat vitamin D resistant rickets

作者: Hiroyuki Tanaka , Yoshiki Seino , Yumiko Nagai

DOI:

关键词:

摘要: A pharmaceutical composition containing 24,25-dihydroxycholecalciferol is provided. The active ingredient used in the present invention an intrinsic and safe substance, so does not exhibit hypercalcemia which side effect induced by conventional antirachitic agents, effective for treatment of rickets, particularly vitamin D resistant rickets.

参考文章(11)
Danielle Hirsch, Ben-Zion Weiner, Jeffrey Sterling, Dinora Barasch, Eliot Slovin, Process for the stereospecific preparation of 24(R),25- and 24(S),25-dihydroxycholecalciferol and novel intermediates used therefor ,(1986)
Heinrich K Schnoes, Michael F Holick, Hector F De Luca, 1,25-dihydroxycholecalciferol ,(1971)
David Ladkani, Ben Zion Weiner, Zeev Mazor, Benjamin Shalita, Shmuel Edelstein, John Anthony Kanis, Mordecai Popovtzer, A combination of cholecalciferol derivatives for the treatment of renal bone disease ,(1988)
Yoko Tanaka, Hector F. DeLuca, Nobuo Ikekawa, Masuo Morisaki, Naoyuki Koizumi, Determination of stereochemical configuration of the 24-hydroxyl group of 24,25-dihydroxyvitamin D3 and its biological importance Archives of Biochemistry and Biophysics. ,vol. 170, pp. 620- 626 ,(1975) , 10.1016/0003-9861(75)90157-5
I. Atkin, J.C. Pita, A. Ornoy, A. Agundez, G. Castiglione, D.S. Howell, Effects of vitamin D metabolites on healing of low phosphate, vitamin D-deficient induced rickets in rats Bone. ,vol. 6, pp. 113- 123 ,(1985) , 10.1016/8756-3282(85)90315-1
E BLAUGRUND, S EDELSTEIN, Responses of rachitic cartilage cells to metabolites of vitamin D3. Cell Biology International Reports. ,vol. 12, pp. 373- 381 ,(1988) , 10.1016/0309-1651(88)90062-8
Enrico Baggiolini, Milan Radoje Uskokovic, John Joseph Partridge, Syntheses of 24R,25- and 24S,25-dihydroxycholecalciferol ,(1976)
Cobi Lidor, Samuel Edelstein, Michael S. Meyer, Samuel Dekel, Method and compositions comprising a vitamin d derivative for the local treatment of bone fractures ,(1986)
Heinrich K. Schnoes, Hector F. DeLuca, Joseph B. Alper, Yoko Tanaka, Derivatives of 25-hydroxycholecalciferol ,(1979)