Unconjugated anti-TfR antibodies and compositions thereof for the treatment of cancer

作者: Tracy R. Daniels , Manuel L. Penichet

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摘要: Disclosed herein are methods and compositions for treating cancer. In particular, the in vivo efficacy of unconjugated anti-TfR antibodies, such as ch128.1, disclosed herein.

参考文章(15)
Armand Bensussan, Jean Kadouche, Laurence Boumsell, Anti-cd71 monoclonal antibodies and uses thereof for treating malignant tumour cells ,(2006)
J F Lesley, R J Schulte, Inhibition of cell growth by monoclonal anti-transferrin receptor antibodies. Molecular and Cellular Biology. ,vol. 5, pp. 1814- 1821 ,(1985) , 10.1128/MCB.5.8.1814
W M Pardridge, P M Friden, L R Walus, R M Starzyk, Enhanced uptake of rsCD4 across the rodent and primate blood-brain barrier after conjugation to anti-transferrin receptor antibodies. Journal of Pharmacology and Experimental Therapeutics. ,vol. 277, pp. 1067- 1075 ,(1996)
Patrick P. Ng, Gustavo Helguera, Tracy R. Daniels, Simon Z. Lomas, Jose A. Rodriguez, Gary Schiller, Benjamin Bonavida, Sherie L. Morrison, Manuel L. Penichet, Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor. Blood. ,vol. 108, pp. 2745- 2754 ,(2006) , 10.1182/BLOOD-2006-04-020263
José A. Rodríguez, Gustavo Helguera, Tracy R. Daniels, Isabel I. Neacato, Héctor E. López-Valdés, Andrew C. Charles, Manuel L. Penichet, Binding specificity and internalization properties of an antibody-avidin fusion protein targeting the human transferrin receptor. Journal of Controlled Release. ,vol. 124, pp. 35- 42 ,(2007) , 10.1016/J.JCONREL.2007.08.020
P. P. Ng, J. S. Dela Cruz, D. N. Sorour, J. M. Stinebaugh, S.-U. Shin, D. S. Shin, S. L. Morrison, M. L. Penichet, An anti-transferrin receptor-avidin fusion protein exhibits both strong proapoptotic activity and the ability to deliver various molecules into cancer cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 10706- 10711 ,(2002) , 10.1073/PNAS.162362999
Ivan C Moura, Yves Lepelletier, Bertrand Arnulf, Patrick England, Cedric Baude, Carole Beaumont, Ali Bazarbachi, Marc Benhamou, Renato C Monteiro, Olivier Hermine, A neutralizing monoclonal antibody (mAb A24) directed against the transferrin receptor induces apoptosis of tumor T lymphocytes from ATL patients Blood. ,vol. 103, pp. 1838- 1845 ,(2004) , 10.1182/BLOOD-2003-07-2440
Yves Lepelletier, Valérie Camara-Clayette, Hulin Jin, Aurélie Hermant, Séverine Coulon, Michaël Dussiot, Michelle Arcos-Fajardo, Cédric Baude, Danielle Canionni, Richard Delarue, Nicole Brousse, Philippe Benaroch, Marc Benhamou, Vincent Ribrag, Renato C. Monteiro, Ivan C. Moura, Olivier Hermine, Prevention of Mantle Lymphoma Tumor Establishment by Routing Transferrin Receptor toward Lysosomal Compartments Cancer Research. ,vol. 67, pp. 1145- 1154 ,(2007) , 10.1158/0008-5472.CAN-06-1962