Enhanced inhibition of tumor cell proliferation using a combination of two monoclonal antibodies to the human transferrin receptor

摘要: Combinations of monoclonal antibodies which are highly effective for inhibiting cell growth and methods employing novel combinations disclosed. The employed capable binding to the human transferrin receptor glycoprotein and, in combination, usually exhibit a substantially greater inhibition than either individually when administered comparable amounts, e.g. at saturation conditions. In preferred combinations, least one member combination is inhibit other ineffective growth. selected based upon an vitro screening test using CCRF-CEM cells express Tf receptor.