Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates

作者: Phillip M. Friden

DOI:

关键词:

摘要: The present invention pertains to a method for delivering neuropharmaceutical or diagnostic agent across the blood brain barrier of host. comprises administering host therapeutically effective amount an antibody-neuropharmaceutical conjugate wherein antibody is reactive with transferrin receptor. Other aspects this include delivery system comprising receptor linked and methods treating hosts afflicted disease associated neurological disorder.

参考文章(81)
W A Jefferies, S V Hunt, A F Williams, M R Brandon, Analysis of lymphopoietic stem cells with a monoclonal antibody to the rat transferrin receptor. Immunology. ,vol. 54, pp. 333- 341 ,(1985)
Ira H. Pastan, David Fitzgerald, An improved toxin for construction of immunotoxins ,(1990)
Arne Nalpon Akbar, Günther Heinrich, Salvatore Cammisuli, Peter Lloyd Amlot, CD 25 binding molecules ,(1991)
J Herz, R C Kowal, Y K Ho, M S Brown, J L Goldstein, Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver. Journal of Biological Chemistry. ,vol. 265, pp. 21355- 21362 ,(1990) , 10.1016/S0021-9258(17)45368-3
Neal Castagnoli, Michael S. Verlander, Kenneth Jacobson, Murray Goodman, Roberto P. Rosenkranz, Kenneth L. Melmon, Drug-carrier conjugates ,(1983)
Robert Pirker, Robert F. Ozols, Mark C. Willingham, David J. P. FitzGerald, Ira Pastan, Thomas C. Hamilton, Anti-transferrin receptor antibody linked to Pseudomonas exotoxin as a model immunotoxin in human ovarian carcinoma cell lines Cancer Research. ,vol. 45, pp. 751- 757 ,(1985)
Guido Volckaert, Jcm Raus, Hr Hoogenboom, Cloning and expression of a chimeric antibody directed against the human transferrin receptor. Journal of Immunology. ,vol. 144, pp. 3211- 3217 ,(1990)