Tumor suppressive miRNA‐34a suppresses cell proliferation and tumor growth of glioma stem cells by targeting Akt and Wnt signaling pathways

作者: Sachin S Rathod , Sandhya B Rani , Mohsina Khan , Dattatraya Muzumdar , Anjali Shiras

DOI: 10.1016/J.FOB.2014.05.002

关键词:

摘要: … Rictor, a defining component of mTORC2 complex, is involved in cell survival … glioma invasion (Das et al., 2011). Here, we demonstrate that miR34a over-expression in glioma stem cells …

参考文章(50)
Richard C. Hresko, Mike Mueckler, mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes Journal of Biological Chemistry. ,vol. 280, pp. 40406- 40416 ,(2005) , 10.1074/JBC.M508361200
Tae-Min Kim, Wei Huang, Richard Park, Peter J. Park, Mark D. Johnson, A Developmental Taxonomy of Glioblastoma Defined and Maintained By MicroRNAs Cancer Research. ,vol. 71, pp. 3387- 3399 ,(2011) , 10.1158/0008-5472.CAN-10-4117
Corbin E. Meacham, Sean J. Morrison, Tumour heterogeneity and cancer cell plasticity Nature. ,vol. 501, pp. 328- 337 ,(2013) , 10.1038/NATURE12624
Costas G. Hadjipanayis, Erwin G. Van Meir, Brain cancer propagating cells: biology, genetics and targeted therapies Trends in Molecular Medicine. ,vol. 15, pp. 519- 530 ,(2009) , 10.1016/J.MOLMED.2009.09.003
Ryan J. Atkins, James Dimou, Lucy Paradiso, Andrew P. Morokoff, Andrew H. Kaye, Katharine J. Drummond, Christopher M. Hovens, Regulation of glycogen synthase kinase-3 beta (GSK-3β) by the Akt pathway in gliomas Journal of Clinical Neuroscience. ,vol. 19, pp. 1558- 1563 ,(2012) , 10.1016/J.JOCN.2012.07.002
Navjot Kaur, Sivarajan Chettiar, Sachin Rathod, Phalguni Rath, Dattatraya Muzumdar, ML Shaikh, Anjali Shiras, None, Wnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma Molecular and Cellular Neuroscience. ,vol. 54, pp. 44- 57 ,(2013) , 10.1016/J.MCN.2013.01.001
Ronglai Shen, Qianxing Mo, Nikolaus Schultz, Venkatraman E. Seshan, Adam B. Olshen, Jason Huse, Marc Ladanyi, Chris Sander, Integrative Subtype Discovery in Glioblastoma Using iCluster PLoS ONE. ,vol. 7, pp. e35236- ,(2012) , 10.1371/JOURNAL.PONE.0035236