Stereoselective Synthesis of Polysubstituted Alkenes through a Phosphine-Mediated Three-Component System of Aldehydes, α-Halo Carbonyl Compounds, and Terminal Alkenes
作者： Da-Neng Liu , Shi-Kai Tian
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摘要: Geometrical control: PPh(3) and methyl acrylate (or acrylamide) are able to mediate the one-pot Wittig reaction of aldehydes with alpha-halo carbonyl compounds for synthesis 1,2-disubstituted trisubstituted alkenes in an excellent stereoselective fashion. Furthermore, first one-pot, three-component aldehydes, acetates, terminal has been developed presence produce E selectivity (see scheme).
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