Nocardithiocin, a novel thiopeptide antibiotic, produced by pathogenic Nocardia pseudobrasiliensis IFM 0757

摘要: Nocardithiocin is a novel thiopeptide compound produced by the pathogenic Nocardia pseudobrasiliensis strain IFM 0757. It shows strong activity against acid-fast bacilli such as Mycobacterium and Gordonia species. was highly active rifampicin-resistant well -sensitive tuberculosis strains, most of resistant strains were inhibited at concentrations ranging from 0.025 to 1.56 microg ml(-1). The structure antibiotic containing thiazole, natural unnatural amino acids elucidated MS NMR spectral analyses.