A multifunctional biphasic suspension of mesoporous silica encapsulated with YVO4:Eu3+ and Fe3O4 nanoparticles: synergistic effect towards cancer therapy and imaging
作者： N Shanta Singh , Hrishikesh Kulkarni , Lina Pradhan , D Bahadur
DOI: 10.1088/0957-4484/24/6/065101
关键词:
摘要: Polyol mediated synthesized luminescent YVO4:Eu3+ nanoparticles (NPs) have been encapsulated in mesoporous silica (MSNs) using the sol?gel process. X-ray diffraction and Fourier transform infrared spectroscopy along with transmission electron microscopy confirm encapsulation of NPs SiO2 matrix. N2 adsorption/desorption analysis confirms nature MSNs YVO4:Eu3+-MSNs. No significant quenching luminescence is observed for This nanocomposite has tested as a potential drug carrier. Efficient loading doxorubicin hydrochloride (DOX), typical anticancer drug, which reaches up to 93% 8?mg?ml?1 pH sensitive release DOX observed, 54% 4.3 31% physiological environment (pH 7.4). Both YVO4:Eu3+-MSNs nanocomposites do not show accountable toxicity two cell lines, i.e. HeLa MCF-7. However, desired, when cells are incubated loaded Laser scanning confocal images uptake both lines. The morphology (MCF-7) changes after incubation YVO4:Eu3+-MSNs, indicating an interaction cells. More cytotoxicity lines ?90% killing due synergistic effect magnetic fluid hyperthermia chemotherapy biphasic suspension superparamagnetic iron oxide In addition, AC field triggers enhanced release.
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