MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis

摘要: Abstract Post-transcriptional regulation of gene expression by microRNA (miRNA) has recently attracted major interest in relation to its involvement cancer development. miRNA is a member small non-coding RNA, consists 22–24 nucleotides and regulates target mRNA species post-transcriptional manner being incorporated with RNA-induced silencing complex (RISC). Staphylococcal nuclease homology domain containing 1 (SND1), component RISC, frequently up-regulated human colon cancers also chemically induced animals. We here showed that SDN1 involved miRNA-mediated suppression overexpression SND1 cells causes down-regulation APC without altering levels. As for the profile cancer, miR-34a was among list down-regulated miRNA. Expression tightly regulated p53, ectopic remarkable reduction cell proliferation induces senescence-like phenotypes. MiR-34a participates positive feedback loop p53 tumor suppressor network. This circuitry mechanism activation understanding suppressive function carcinogenesis. should be considered as novel anti-cancer agents therapeutic applications.