Usefulness of non-invasive serum markers for predicting liver fibrosis in Egyptian patients with chronic HCV infection.

摘要: Accurate monitoring of liver fibrosis changes in patients with hepatitis C virus (HCV) infection would be helpful defining the need to intervene, implement appropriate response treatment and minimize use biopsy. We aimed evaluate diagnostic utility different serum markers indices detecting study patients. Initial biopsy, routine function tests, estimation hyaluronic acid, MMP-1, PIIINP levels was performed for 30 Egyptian HCV 15 controls. Marker algorithms based on common laboratory such APRI score, Fibrotest Actitest. MMP-1 were combined entered into a stepwise logistic regression analysis formulation score equation staging. Combined yielded cut off scores estimate two clinically relevant stages: “significant fibrosis” versus “extensive fibrosis. Apri also showed AUC 1.0 100 % sensitivity specificity exclude presence cirrhosis significantly correlated Metavair stage early On other hand, PIIINP, acti test both late In conclusion, integrating / able provide reliable information about degree chronic using cut-offs values. A combination as well its related is an emerging tool differentiate from advanced omplication diseases possible development followed by cirrhosis. Arround 170 million individuals (3% world’s population) are infected (HCV); which almost ¾ become carriers risk developing diseases; further 2 5% may develop