Genetics of drug resistance in epilepsy.

摘要: Drug resistance is a major clinical problem in epilepsy, affecting one three patients. It likely to have complex multifactorial basis, with environmental and genetic contributions. Knowledge of robust factors underlying drug might both improve prediction permit the development novel rational treatments for resistance. A number association studies been undertaken examining effect range candidate genes Although some these candidates good biologic motivation mediating resistance, currently there are no common variants proven generate phenomenon Much work remains be done, but scene set exciting developments that will hold therapeutic potential patients drug-resistant epilepsy.