Cutting Edge: Clec9A+ Dendritic Cells Mediate the Development of Experimental Cerebral Malaria
作者： Lucia Piva , Piotr Tetlak , Carla Claser , Klaus Karjalainen , Laurent Renia
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摘要: Plasmodium infections trigger strong innate and acquired immune responses, which can lead to severe complications, including the most feared often fatal cerebral malaria (CM). To begin dissect roles of different dendritic cell (DC) subsets in Plasmodium-induced pathology, we have generated a transgenic strain, Clec9A-diphtheria toxin receptor that allows us ablate vivo Clec9A(+) DCs. Specifically, analyzed contribution this DC subset an experimental CM model using berghei, provide evidence absence resulted complete resistance CM. This was accompanied with dramatic reduction brain CD8(+) T cells, those few cells present had less activated phenotype, unlike their wildtype counterparts expressed IFN-γ especially granzyme B. almost local cellular responses also associated reduced parasite load brain.
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