Advancing prediction of tissue distribution and volume of distribution of highly lipophilic compounds from a simplified tissue‐composition‐based model as a mechanistic animal alternative method
作者： Patrick Poulin , Sami Haddad
DOI: 10.1002/JPS.23090
关键词:
摘要: … in prediction methods of tissue distribution would be … restricted by the physiology above a certain log P ow value. … fu t for nonadipose tissue were computed from log P ow only, …
sci-hub.se 参考文章(42)
Koichi Yokogawa, Emi Nakashima, Junko Ishizaki, Hitoshi Maeda, Taizo Nagano, Fujio Ichimura, Relationships in the Structure–Tissue Distribution of Basic Drugs in the Rabbit Pharmaceutical Research. ,vol. 7, pp. 691- 696 ,(1990) , 10.1023/A:1015803202857
Patrick Poulin, Martin Beliveau, Kannan Krishnan, Mechanistic Animal-Replacement Approaches for Predicting Pharmacokinetics of Organic Chemicals Humana Press, Totowa, NJ. pp. 115- 139 ,(1999) , 10.1007/978-1-59259-718-5_11
Greet Cauwenbergh, Paul Stoffels, Focus on itraconazole Indian Journal of Dermatology, Venereology and Leprology. ,vol. 57, pp. 4- 16 ,(1991)
Patrick Poulin, Sean Ekins, Frank-Peter Theil, A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human Toxicology and Applied Pharmacology. ,vol. 250, pp. 194- 212 ,(2011) , 10.1016/J.TAAP.2010.10.014
Patrick Poulin, Sami Haddad, Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes Journal of Pharmaceutical Sciences. ,vol. 100, pp. 4501- 4517 ,(2011) , 10.1002/JPS.22619
Vera Fiserova-bergerova, Milon Tichy, Frederick J. di Carlo, Effects of biosolubility on pulmonary uptake and disposition of gases and vapors of lipophilic chemicals. Drug Metabolism Reviews. ,vol. 15, pp. 1033- 1070 ,(1984) , 10.3109/03602538409033557
Patrick Poulin, Frank-Peter Theil, Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods Journal of Pharmaceutical Sciences. ,vol. 98, pp. 4941- 4961 ,(2009) , 10.1002/JPS.21759
Max von Kleist, Wilhelm Huisinga, Physiologically based pharmacokinetic modelling: a sub-compartmentalized model of tissue distribution. Journal of Pharmacokinetics and Pharmacodynamics. ,vol. 34, pp. 789- 806 ,(2007) , 10.1007/S10928-007-9071-3
Leonid M. Berezhkovskiy, Volume of Distribution at Steady State for a Linear Pharmacokinetic System with Peripheral Elimination Journal of Pharmaceutical Sciences. ,vol. 93, pp. 1628- 1640 ,(2004) , 10.1002/JPS.20073
TOSHIYA MINAGAWA, YOSHIRO KOHNO, TOSHIO SUWA, AKIRA TSUJI, Determination of protein binding of a highly lipophilic drug, isocarbacyclin methyl ester (TEI-9090), using a polydimethylsiloxane-coated glass beads assay. Journal of Pharmacy and Pharmacology. ,vol. 46, pp. 838- 843 ,(2011) , 10.1111/J.2042-7158.1994.TB03740.X