REACTION OF FISH INSULINS WITH HUMAN INSULIN ANTISERUMS. POTENTIAL VALUE IN THE TREATMENT OF INSULIN RESISTANCE.

作者: Rosalyn S. Yalow , Solomon A. Berson

DOI: 10.1056/NEJM196405282702207

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摘要: VIRTUALLY all human subjects treated with insulin shortly develop circulating insulin-binding antibodies that are demonstrable by a variety of technics employing I131-labeled insulin.1 2 3 The formation insulin-antibody complexes in antiserums is reversible reaction for which various kinetic and thermodynamic constants have been determined quantitatively.4 Insulin-binding capacities from not clinically resistant to rarely exceed 10 20 units per liter plasma whereas binding but 1 54 insulin-resistant ranged 57 4700 liter.5 Although individual showed similar . . .

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