Biomedical Applications of Organometal–Peptide Conjugates

摘要: Peptides are well suited as targeting vectors for the directed delivery of metal-based drugs or probes biomedical investigations. This chapter describes synthetic strategies preparation conjugates medically interesting peptides with covalently bound metal complexes. that were used include neuropeptides (enkephalin, neuropeptide Y, neurotensin), uptake (TAT and poly-Arg), intracellular localization sequences. To these peptides, a whole variety transition complexes has been attached in recent years by solid-phase peptide synthesis (SPPS) techniques. The complex can be to on resin part SPPS scheme. Alternatively, may postsynthetic modification. Advantages disadvantages either strategy discussed. Biomedical applications radiopharmaceutical applications, anticancer antibacterial activity, metal–peptide targeted CO-releasing molecules, biosensor applications.