Ruthenium complexes as antimicrobial agents.

摘要: One of the major advances in medical science has been development antimicrobials; however, a consequence their widespread use emergence drug-resistant populations microorganisms. There is clearly need for new antimicrobials – but more importantly, there classes antimicrobials, rather than drugs based upon analogues known scaffolds. Due to success platinum anticancer agents, considerable interest therapeutic agents other transition metals and particular ruthenium(II/III) complexes, due well interaction with DNA. have many studies properties cellular localisation range ruthenium complexes eukaryotic cells over last decade. However, only very recently significant antimicrobial properties. This review highlights types that exhibited activity discusses relationship between chemical structure biological processing including site(s) intracellular accumulation both bacterial cells.