Milk Alkali Syndrome and the Dynamics of Calcium Homeostasis

摘要: Intensive treatment with calcium-containing antacids and milk first was used in the early 20th century for of peptic ulcer disease sometimes associated toxicity, eventually known as alkali syndrome. Despite introduction H2 blockers proton pump inhibitors disease, syndrome continues to occur but is seen more frequently older women who are receiving osteoporosis. The provides a unique opportunity discuss calcium homeostasis setting which primary regulatory hormones, parathyroid hormone (PTH) calcitriol, not overtly abnormal. A thorough understanding pathophysiology syndrome, including its generation maintenance, requires knowledge intestinal absorption, bone influx efflux calcium, renal excretion also how these processes change age. In this review, discussed light recent advances our homeostasis, particularly role calcium-sensing receptor (CaSR) epithelial channels that present various tissues such gland, kidney, intestine. contributions alkalosis, per se , maintenance hypercalcemia detail. Almost 100 years ago, Sippy (1) developed calcium-laden antacid regimen disease. His rationale neutralize hyperacidity deemed responsible disorder most common middle-aged men, until 1970s, when nonantacid introduced (2–4). original recommendation by consisted hourly administration cream together what became …