Esthesioneuroblastoma: Is There a Need for Elective Neck Treatment?

摘要: Purpose To assess the risk of cervical lymph node metastases after definitive treatment for esthesioneuroblastoma (ENB) that did not include elective neck therapy. Methods and Materials This was a retrospective analysis 26 ENB patients treated at University Michigan between 1995 2007. Tumor stage Kadish A in 1 patient, B 19, C 5, unknown 1. Craniofacial or subcranial resection performed 24 (92%), with negative margins 22 (92%). Postoperative radiotherapy (RT) to primary site given 12 (46%), 14 (54%) had surgery alone. All clinically N0 disease, no patient underwent dissection radiation. Median follow-up 72 months. Results Local relapse-free survival significantly better who received postoperative RT compared those alone: 100% vs. 29% 5 years, respectively ( p  = 0.005). Five-year disease-free 87.5% group 31% surgery-alone 0.05). Regional failure observed 7 (27%), 6 Stage disease. The most common nodal Level II, 3 failed contralateral neck. Only regional were successfully salvaged. Conclusion high rate failures when is electively justifies both Stages C. In addition, our experience confirms beneficial effect on local control adjuvant tumor bed.