Induction of Antitumor Reactive Cells or Suppressor Cells by Different Molecular Species Isolated from the Same Nonimmunogenic Tumor

摘要: Abstract The inability of spontaneous and some laboratory-induced tumors to stimulate the immune system has continuously raised question validity using immunological maneuvers in order control tumor growth. In this project we suggest that a which is nonimmunogenic still an immunogenic potential can be revealed used antitumor immunity consequently destruction. YAC, Moloney-virusinduced A mice, failed responses. This homogenate was exposed nonreduced sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). At end electrophoresis, gels were sliced injected sequential into various groups mice. It found slices (usually with M.W. 100 K or less) induced cytotoxic responses, whereas other about 150 K) suppressor cells. Similarly, certain cells inhibited vivo growth, others enhanced These last two types did not present same cellular population mediated cytotoxicity suppressive effects respectively. concluded poorly do possess after dissociation between suppressogenic entities.