MDM2 Promoter Polymorphism Is Associated With Both an Increased Susceptibility to Gastric Carcinoma and Poor Prognosis
作者： Naoki Ohmiya , Ayumu Taguchi , Nobuyuki Mabuchi , Akihiro Itoh , Yoshiki Hirooka
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摘要: Purpose Recently, a single-nucleotide polymorphism in the MDM2 promoter (SNP309) has been found to lower age of onset tumors and increase occurrence multiple primary Li-Fraumeni syndrome, accelerate development sporadic adult soft tissue sarcoma. The aim this study was determine whether SNP309 is associated with susceptibility gastric carcinoma its prognosis. Patients Methods In case-control including 438 controls 410 patients carcinoma, genotyped. Serum pepsinogens (PGs) I II were measured control subjects 253 cases selected from patients. Tumor immunostained p53 examined for mutations exons 5 8 using polymerase chain reaction–based single strand conformational analysis direct sequencing. Results risk overall (G/G) significantly increased when compared T carriers (P = .039), especially carcin...
sci-hub.se 参考文章(45)
Natalia S. Pellegata, Guglielmina N. Ranzani, Dino Amadori, Juul Wijnen, Riccardo Fodde, P. Meera Khan, Beatrice Renault, Marianne van den Broek, Base Transitions Are the Most Frequent Genetic Changes at P53 in Gastric Cancer Cancer Research. ,vol. 53, pp. 2614- 2617 ,(1993)
Yoshio Yamaoka, Tadashi Kodama, Oscar Gutierrez, Jong G. Kim, Kei Kashima, David Y. Graham, Relationship between Helicobacter pylori iceA, cagA, and vacA Status and Clinical Outcome: Studies in Four Different Countries Journal of Clinical Microbiology. ,vol. 37, pp. 2274- 2279 ,(1999) , 10.1128/JCM.37.7.2274-2279.1999
Berenice H. G. Lim, Richie Soong, Fabienne Grieu, Peter D. Robbins, Anthony K. House, Barry J. Iacopetta, p53 accumulation and mutation are prognostic indicators of poor survival in human gastric carcinoma. International Journal of Cancer. ,vol. 69, pp. 200- 204 ,(1996) , 10.1002/(SICI)1097-0215(19960621)69:3<200::AID-IJC9>3.0.CO;2-3
Emad M El-Omar, Charles S Rabkin, Marilie D Gammon, Thomas L Vaughan, Harvey A Risch, Janet B Schoenberg, Janet L Stanford, Susan T Mayne, James Goedert, William J Blot, Joseph F Fraumeni, Wong-ho Chow, Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms Gastroenterology. ,vol. 124, pp. 1193- 1201 ,(2003) , 10.1016/S0016-5085(03)00157-4
C.M. Fenoglio-Preiser, J. Wang, G.N. Stemmermann, A. Noffsinger, TP53 and gastric carcinoma: a review. Human Mutation. ,vol. 21, pp. 258- 270 ,(2003) , 10.1002/HUMU.10180
E.J. Kuipers, Review article: exploring the link between Helicobacter pylori and gastric cancer Alimentary Pharmacology & Therapeutics. ,vol. 13, pp. 3- 11 ,(1999) , 10.1046/J.1365-2036.1999.00002.X
Young-Woon Chang, Jae-Young Jang, Nam-Hoon Kim, Jae Won Lee, Hyo Jung Lee, Woon Won Jung, Seok-Ho Dong, Hyo-Jong Kim, Byung-Ho Kim, Joung-Il Lee, Rin Chang, Interleukin-1B (IL-1B) polymorphisms and gastric mucosal levels of IL-1β cytokine in Korean patients with gastric cancer International Journal of Cancer. ,vol. 114, pp. 465- 471 ,(2005) , 10.1002/IJC.20724
Naoki Ohmiya, Sandra Matsumoto, Hiroyuki Yamamoto, Svetlana Baranovskaya, Sergei R. Malkhosyan, Manuel Perucho, Germline and somatic mutations in hMSH6 and hMSH3 in gastrointestinal cancers of the microsatellite mutator phenotype. Gene. ,vol. 272, pp. 301- 313 ,(2001) , 10.1016/S0378-1119(01)00517-0
D. Wink, K. Kasprzak, C. Maragos, R. Elespuru, M Misra, T. Dunams, T. Cebula, W. Koch, A. Andrews, J. Allen, al. et, DNA deaminating ability and genotoxicity of nitric oxide and its progenitors Science. ,vol. 254, pp. 1001- 1003 ,(1991) , 10.1126/SCIENCE.1948068
Nickolas Papadopoulos, Nicholas C Nicolaides, Ying-Fei Wei, Steven M Ruben, Kenneth C Carter, Craig A Rosen, William A Haseltine, Robert D Fleischmann, Claire M Fraser, Mark D Adams, J Craig Venter, Stanley R Hamilton, Gloria M Petersen, Patrice Watson, Henry T Lynch, Päivi Peltomäki, Jukka-Pekka Mecklin, Albert De La Chapelle, Kenneth W Kinzler, Bert Vogelstein, Mutation of a mutL homolog in hereditary colon cancer Science. ,vol. 263, pp. 1625- 1629 ,(1994) , 10.1126/SCIENCE.8128251