Associations of MDM2 SNP309, Transcriptional Activity, mRNA Expression, and Survival in Stage I Non-Small-Cell Lung Cancer Patients with Wild-Type p53 Tumors
作者： Wen-Pin Chien , Ruey-Hong Wong , Ya-Wen Cheng , Chih-Yi Chen , Huei Lee
DOI: 10.1245/S10434-009-0853-2
关键词:
摘要: Background Mouse double minute 2 (MDM2) is a negative regulator of p53. In the present study, we examined MDM2 transcriptional activity and messenger RNA (mRNA) expression in lung tumors with respect to SNP309 genotypes p53 mutation status, effects status on cancer prognosis.
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