Lack of Prognostic Significance of p53 and K-ras Mutations in Primary Resected Non–Small-Cell Lung Cancer on E4592: A Laboratory Ancillary Study on an Eastern Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy
作者： Joan H. Schiller , Sudeshna Adak , Richard H. Feins , Steven M. Keller , Willard A. Fry
DOI: 10.1200/JCO.2001.19.2.448
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摘要: PURPOSE: To determine the prognostic and predictive significance of p53 K-ras mutations in patients with completely resected non–small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Patients were randomized preoperatively to receive adjuvant postoperative radiotherapy (Arm A) or plus concurrent chemotherapy B). protein expression was studied by immunohistochemistry (IHC) exons 5 8 evaluated single-strand conformational analysis. codons 12, 13, 61 determined using engineered restriction fragment length polymorphisms. RESULTS: Four hundred eighty-eight entered onto E3590; 197 tumors assessable for Neither presence nor absence mutations, expression, correlated survival progression-free survival. There a trend toward improved wildtype (median, 42 months) compared mutant who wer...
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